Anti-EstrogenSteroidsFaslodexHormoneFulvestrant129453-61-8ForCancerTreatmentCAS:129453-61-8Synonyms:FaslodexAstraZenecaChemicalName:(7A,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diolMolecularFomular:C32H47F5O3SMolecularWeight:606.77Density:1.201g/cm3MeltingPoint:104-106BoilingPoint:674.8at760mmHgAppearance:WhitepowderUsage:Antineoplastic(hormonal)skype:tracy665emailtracyatycphardotcomStorage:Shading,confinedpreservationUsage:Fulvestrantisatypeofhormonetreatment.ItisalsocalledFaslodex.Itisatreatmentforpostmenopausalwomenwithadvancedbreastcancer.Anovelsteroidalestrogenantagonistreportedtolackanypartialagonistactivity.Alsousedasanantineoplasticrawmaterials.Description:Fulvestrantisadrugtreatmentofhormonereceptor-positivemetastaticbreastcancerinpostmenopausalwomenwithdiseaseprogressionfollowinganti-estrogentherapy.Itisanestrogenreceptorantagonistwithnoagonisteffects,whichworksbothbydown-regulatingandbydegradingtheestrogenreceptor.Itisadministeredasaonce-monthlyinjection.Application:Fulvestrant(Faslodex,AstraZeneca)isadrugtreatmentofhormonereceptor-positivemetastaticbreastcancerinpostmenopausalwomenwithdiseaseprogressionfollowinganti-estrogentherapy.Itisanestrogenreceptorantagonistwithnoagonisteffects,whichworksbydown-regulatingtheestrogenreceptor.Fulvestrantisaselectiveestrogenreceptordown-regulator(SERD).Fulvestrantisindicatedforthetreatmentofhormonereceptorpositivemetastaticbreastcancerinpostmenopausalwomenwithdiseaseprogressionfollowinganti-estrogentherapy.Thedosingscheduleforfulvestrantremainsunderinvestigationinanattempttooptimizeitseffectiveness.Fulvestrantprovidedeffectivesecond-linetherapyinthissettingforpostmenopausalwomenwhohadrelapsedorprogressedafterpreviousendocrinetherapy.Inparticular4clinicaltrialsinthissettingdidshowsimilarefficacytotheotherhormonalagents(aromataseinhibitorsand***)withgoodtolerabilityprofile.Fulvestranthadalowerincidenceofjointdisorders.Manybreastcancersarestimulatedtogrowbythefemalesexhormonesoestrogenandprogesterone.Thesebreastcancersarecalledhormonesensitiveorhormonereceptorpositive.Drugsthatblocktheeffectsofthesehormonescansloworstopthegrowthofthebreastcancercells.Fulvestrantstopsoestrogengettingtothecancercellsbyblockingoestrogenreceptorsandreducingthenumberofreceptorsthecancercellhas.)