L-Triiodothyronine(T3)CAS55-06-1CASNo:55-06-1Chemicalname:3,3',5-Triiodo-L-thyronine,sodiumsaltMolecularformula:C15H12I3NO4MolecularWeight:650.97Content:(%):99Boilingpoint:205Water-solubility:4MNH4OHinmethanol:125g/5mL,clear,yellow-brownskype:tracy665emailtracyatycphardotcomQuickDetail:1)CASNO:55-06-12)EINECS:200-223-53)Chemicalname:3,3',5-Triiodo-L-thyronine,sodiumsalt4)Molecularformula:C15H11I3NNaO45)MolecularWeight:690.97066)Assay:99%7)Boilingpoint:205℃9)Usage:Itaffectsalmosteveryphysiologicalprocessinthebody,includinggrowthanddevelopment,metaboli***,bodytemperature,andheartrate,suchas,treatmentofdepressivedisordersanduseasafatlosssupplement.Description:A.Treatmentofdepressivedisorders:TheadditionoftriiodothyroninetoexistingtreatmentssuchasSSRIsisoneofthemostwidelystudiedaugmentationstrategiesforrefractorydepression,howeversuccessmaydependonthedosageofT3.Along-termcaseseriesstudybyKellyandLiebermanof17patientswithmajorrefractoryunipolardepressionfoundthat14patientsshowedsustainedimprovementofsymptomsoveran***eragetimespanoftwoyears,insomecaseswithhigherdosesofT3thanthetraditional50µgrequiredtoachievetherapeuticeffect,withan***erageof80µgandadosagespanof24months;doserange:25-150µg.Thesameauthorspublishedaretrospectivestudyof125patientswiththetwomostcommoncategoriesofbipolardisordersIIandNOSwhosetreatmenthadpreviouslybeenresistanttoan***erageof14othermedicati***.Theyfoundthat84%experiencedimprovementand33%experiencedfullremissionoveraperiodofan***erageof20.3(standarddeviationof9.7).NoneofthepatientsexperiencedhypomaniawhileonT3.B.Useasafatlosssupplement:3,5-Diiodo-L-thyronineand3,3'-diiodo-L-thyronineareusedasingredientsincertainover-the-counterfat-losssupplements,designedforbodybuilding.Severalstudiesh***eshownthatthesecompoundsincreasethemetabolizationoffattyacidsandtheburningofadiposefattissueinrats.Applicati***:IntendeduseImmunoassayfortheinvitroquantitativedeterminationoffreetriiodothyronineinhumanserum.SummaryTriiodothyronineisoneofthethyroidhormonespresentinserumwhichregulatesmetaboli***.Determinationofthishormoneconcentrationisimportantforthediagnosticdifferentiationofeuthyroid,hyperthyroid,andhypothyroidstates.Themajorfractionoftotaltriiodothyronineisboundtothetransportproteins(TBG,prealbumin,albumin).Freetriiodothyronine(fT3)isthephysiologicallyactiveformofthethyroidhormonetriiodothyronine(T3).ThedeterminationoffreeT3hastheadvantageofbeingindependentofchangesintheconcentrati***andbindingpropertiesofthebindingproteins;additionaldeterminationofabindingparameter(T-uptake,TBG)isthereforeunnecessary.(1,2,3)Innormalthyroidfunction,astheconcentrati***ofthecarrierproteinsalter,thetotalT3levelchangessothattheFT3concentrationremainsc***tant.(4)Thus,measurementsofFT3concentrati***correlatemorereliablywithclinicalstatusthantotalT3levels.Forexample,theincreaseintotalT3levelsassociatedwithpregnancy,oralcontraceptivesandestrogentherapyresultinhighertotalT3levelswhiletheFT3concentrationremainsbasicallyunchanged.(5)Inaddition,ithasbeenfoundthatthemeanFT3valuehasagradientdecreasinfromyoungtoolder.(6))