ProgesteroneHormonesChlormadinoneacetate(CASNo.302-22-7)CMAQuickdetails:ChlormadinoneacetateProductname:ChlormadinoneacetateCASRegistryNumber:302-22-7Assay:98%MolecularFormula:C23H29ClO4Molecularweight:404.93ReferenceStandard:CPAppearance:WhiteorslightlyyellowcrystallinepowderAlsoknownas:Gestafortin,Menstridyl,Matrol,Cero,Chlormadinonacetate,Bovisynchron,Fertiletten,Chlordion,ClordionMolecularFormula:C23H29ClO4MolecularWeight:404.92696InChIKey:QMBJSIBWORFWQT-DFXBJWIESA-NAnorallyactivesyntheticprogestationalhormoneusedoftenincombinati***asanoralcontraceptive.Description:Chlormadinoneacetate(INN,USAN,BAN,JAN;soldunderbrandnamesincludingClordion,Gestafortin,Lormin,Non-Ovlon,Normenon,Verton,andmanyothers)(CMA)isaderivativeofprogesterone(17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione),firstsynthesizedin1961andisusedasanorallyeffectiveprogestogeninhormonereplacementtherapy(HRT),andincombinationwithethinylestradiol(EE)incontraceptionsince1999.Chlormadinoneacetatehasastrongprogestogeniceffect-aboutone-thirdhigherthanthatofprogesterone-andmayvarydependingonthepreviouseffectofanestrogen,i.e.,estrogensmaypromotetheformationofprogesteronereceptorsandproliferationoftheendometrium.Likeprogesterone,itisanti-estrogenicandhasnopartialandrogeniceffect(atthedosesusedforcontraceptionandHRT).Incontrasttoprogesterone,ithasaslightglucocorticoideffect,apronouncedanti-androgeniceffectandnoanti-mineralocorticoideffect.Nopregnancy-maintainingeffectofCMAhasbeendem***tratedinhumans.Theanti-androgeniceffectofCMAispresumedtobetheresultofbothitsbindingtoandrogenreceptors-competitivelyinhibitingtheeffectofendogenous***anddihydro***-andthecompetitiveinhibitionof5α-reductase.Inthisrespect,dosingofCMAiscrucial;agonisticeffectsareobservedwhendosesareincreasedfromthoseoptimalforanantagonisticeffect.Applicati***:Chlormadinoneacetateisasteroidalprogestinwithadditionalantiandrogenandantigonadotropic(andthusalsoantiestrogenic)effects.Itisusedclinicallyasahormonalcontraceptive,andinpartduetoitsloweringofestrogenlevels,butalsoforimprovedeffectivenessincontraception,chlormadinoneisfrequentlycombinedwithethinylestradiolforthispurpose.Chlormadinoneacetatehasastronganti-gonadotropiceffect,throughnegativefeedbackongonadotropinsecretion,andhasbeenusedformorethan20yearsaloneforcontraceptioninarterialriskpatients.TheclinicalandmetabolictolerabilityofCMAhasbeendem***tratedinnumerousclinicalstudieswithdurationoftreatmentofupto2.5years.skype:edisonxu0907emailsales02atycphardotcom)