HighpurityLevonorgestrelProgesteroneHormonesCAS6533-00-2NorgestrelCAS:6533-00-2Formula:C21H28O2MolecularWeight:312.45Synonyms:13-Ethyl-17A-ethynyl-17b-hydroxy-4-gonen-3-one;DL-Norgestrel;Methylnorethindrone;A-Norgestrel;EINECS:229-433-5Density:1.139g/cm3MeltingPoint:239-241°C(lit.)BoilingPoint:459.139°Cat760mmHgFlashPoint:195.446°CAppearance:WhitesolidPurity:99%Standard:USP32Package:1kg/foilbagoraccordingtothecustomersrequirement.Storage:RoomtemperatureUsageProgestogen;oralcontraceptive.Thebioactiveenantiomerislevorotatory,AmetaboliteofNorgestrel.Description:Levonorgestrel(orl-norgestrelorD-norgestrel)(PlanB,NextChoice,Postinor,"themorningafterpill,"andothers)isasecondgenerationprogestin(syntheticprogestogen)usedasanactiveingredientinsomehormonalcontraceptives,includingcombinedoralcontraceptivepills,progestogenonlypills,emergencycontraceptivepills,intrauterinesystems,contraceptiveimplants,andhormonereplacementtherapy.ItisontheWorldHealthOrganization'sListofEssentialMedicines,alistofthemostimportantmedicationneededinabasichealthsystem.Usage&Dosing:(1)Oralcontraception:Atlowdoses,levonorgestrelisusedinmonophasicandtriphasicformulati***ofcombinedoralcontraceptivepills,with***ailablemonophasicdosesrangingfrom100-250μg,andtriphasicdosesof50μg/75μg/125μg.Atverylowdailydoseof30μg,levonorgestrelisusedinsomeprogestogenonlypillformulati***.(2)Emergencycontraception:Levonorgestrelisusedinemergencycontraceptivepills(ECPs),bothinacombinedYuzperegimenwhichincludesestrogen,andasalevonorgestrel-onlymethod.Thelevonorgestrel-onlymethoduseslevonorgestrel1.5mg(asasingledoseorastwo0.75mgdoses12hoursapart)takenwithin3daysofunprotectedsex,withonestudyindicatingthatbeginningaslateas120hours(5days)afterintercoursecouldbeeffective.Theprimarymechani***ofactionoflevonorgestrelasaprogestogen-onlyemergencycontraceptivepillis,accordingtoFIGO,topreventfertilizationbyinhibitionofovulation.TheInternationalFederationofGynecologyandObstetrics(FIGO)hasissuedastatementthat:"reviewoftheevidencesuggeststhatLNG[levonorgestreol]ECPscannotpreventimplantationofafertilizedegg.LanguageonimplantationshouldnotbeincludedinLNGECPproductlabeling."InJune2012,aNewYorkTimeseditorialcalledontheFoodandDrugAdministration(FDA)toremovefromthelabeltheunsupportedsuggestionthatlevonorgestrelemergencycontraceptivepillsinhibitimplantation.InNovember2013,theEuropeanMedicinesAgency(EMA)approvedachangetothelabelforHRAPharma'sNorLevosayingitcannotpreventimplantationofafertilizedegg.InNovember2013,theEMAalsoapprovedachangetothelabelforHRAPharma'sNorLevosaying:"Inclinicaltrials,contraceptiveefficacywasreducedinwomenweighing75kg[165pounds]ormore,andlevonorgestrelwasnoteffectiveinwomenwhoweighedmorethan80kg[176pounds]."InNovember2013andJanuary2014,theFDAandtheEMAsaidtheywerereviewingwhetherincreasedweightandbodymassindex(BMI)reducetheefficacyofemergencycontraceptives.LevonorgestrelisalsousedinIntrauterinesystem,ContraceptiveimplantsandHormonereplacementtherapy.COA:ItemsSpecificationResultsDescriptionWhiteorpracticallywhitecrystallinepowderWhitecrystallinepowderSpecificRotation30¡ã~-35¡ã32¡ãMeltingRange232~239¡ãC,andmeltingrangeisnotmorethen4¡ãC234~238¡ãCidentificationItcomplieswiththetestforspecificopticalrotationandmeltingpointConformsInfraredabsorptionspectrophotometryshouldbec***istentwithlevonorgestrelCRSConformsLossondrying¡Ü0.5%0.20%Residueonignition¡Ü0.3%0.07%LimitofEthynylGroup7.81%~8.18%7.92%RelatedsubstancesSingleimpurity¡Ü0.5%singleimpurity<0.5%TotalImpurities¡Ü2.0%Totalimpurities<2.0%OrganicVolatileimpurtiesEthanol¡Ü5000ppm1200ppmAssayTheproductcomplieswithspecificationinUSP34ParticleSizeD(0.9)<10¦&Igr***e;mStorageConditionSealed,protectfromlightOuradvantage:1,Offerwithbestqualityaswellasmorecompetitiveprice2,wellexperiencedindeliveringtheparcelstoyou.3,Enoughstockensurethepromptdeliverytime.4,Goodafter-salesservice.skype:edisonxu0907emailtracyatycphardotcom)