Prednisolone-21-acetate1.Name:Prednisolone-21-acetate2.CASNo.52-21-13.Appearance:Whitecrystalpowder4.Purity:99%5.Effect:Syntheticcorticosteroid;Metabolicallyinterconvertiblewithprednisone.ProductnamePrednisolone-21-acetateAppearancewhitecrystallinepowderMeltingPoint240-244°CMolecularFormulaC23H30O6MolecularWeight402.48CasNo.52-21-1EINECSNo.200-134-1Functi***Syntheticcorticosteroid;metabolicallyinterconvertiblewithprednisone.Applicati***PharmaceuticalPackageAluminumfoilbaginside+cartonboxoutside;1kg/bag+25kg/drumStorageStoreinacoolanddryplace,keepawayfromdirectstrongandheat.ShelfLifeTwoyearsifsealedandstoreawayfromdirectsunlight.Productdescription:Prednisoloneisasyntheticglucocorticoid,aderivativeofcortisol,whichisusedtotreatavarietyofinflammatoryandauto-immuneconditi***.Itistheactivemetaboliteofthedrugprednisone[1]andisusedespeciallyinpatientswithhepaticfailure,astheseindividualsareunabletometaboliseprednisoneintoprednisolone.Prednisoloneisacorticosteroiddrugwithpredominantglucocorticoidandlowmineralocorticoidactivity,makingitusefulforthetreatmentofawiderangeofinflammatoryandauto-immuneconditi***suchasasthma,uveitis,pyodermagangrenosum,rheumatoidarthritis,ulcerativecolitis,pericarditis,temporalarteritisandCrohn'sdisease,Bell'spalsy,multiplesclerosis,clusterheadaches,vasculitis,acutelymphoblasticleukemiaandautoimmunehepatitis,systemiclupuserythematosus,Kawasakidiseaseanddermatomyositis.Itisalsousedfortreatmentofsarcoidosis,thoughthemechani***isunknown.Prednisoloneacetateophthalmicsuspension(eyedrops)isanadrenocorticalsteroidproduct,preparedasasterileophthalmicsuspensionandusedtoreduceswelling,redness,itching,andallergicreacti***affectingtheeye.Prednisolonecanalsobeusedasanimmunosuppressivedrugfororgantransplantsandincasesofadrenalinsufficiency(Addison'sdisease).Corticosteroidsinhibittheinflammatoryresp***etoavarietyofincitingagentsand,itispresumed,delayorslowhealing.Theyinhibittheedema,fibrindeposition,capillarydilation,leukocytemigration,capillaryproliferation,fibroblastproliferation,depositionofcollagen,andscarformationwithinflammation.Possibleside-effectsincludefluidretentionoftheface(moonface,Cushing'ssyndrome),acne,c***tipation,andmoodswings.Alengthycourseofprednisolonecancausebloodyorblacktarrystoolsfrombleedingintothestomach(thisrequiresurgentmedicalattention);fillingorroundingoutoftheface;musclecrampsorpain;muscleweakness;nausea;paininback,hips,ribs,arms,shoulders,orlegs;reddish-purplestretchmarksonarms,face,legs,trunk,orgroin;thinandshinyskin;unusualbruising;urinatingatnight;rapidweightgain;andwoundsthatwillnotheal.Prolongeduseofprednisolonecanleadtothedevelopmentofosteoporosiswhichmakesbonesmorefragileandsusceptibletofractures.OnewaytohelpalleviatethissideeffectisthroughtheuseofcalciumandvitaminDsupplements.COA:ProductnamePrednisolone-21-acetateAppearanceWhitecrystallinepowderChromatographicpurityAnyindividualimpuritynotmorethan1.0%Totalimpuritiesnotmorethan2.0%0.4%1.2%LossondryingNotmorethan0.5%0.3%ResidueonignitionNotmorethan0.2%0.05%ResidualsolventsMethanol¡Ü3000ppmMethyleneChloride¡Ü600ppmChloroform¡Ü60ppmTetrahydrofuran¡Ü720ppm385ppmNotdetectoutNotdetectoutNotdetectoutAssayBetween97.0%and102.0%98.8%Micronixation90%notmorethan10micr***90%notmorethan10aicr***)