WeightLossSteroidsWhitePharmaceuticalIntermediatesPowderRimonabantHydrochlorideForFatLossAndBodyShaper1.QuickDetail:productnameRimonabanthydrochlorideAliasRIMONABANTHCL;Rimonabant(Acomplia)CAS158681-13-1MolecularFormulaHMolecularWeight500.25AppearanceswhiteoroffwhitesolidUsagepharmaceuticalintermediates2.Description:Rimonabanthydrochloride(SR-141716A)isapotentandselectiveCB1cannabinoidinverseagonist/antagonistwithaKiof1.6nM,minimalaffinityforCB2,andandsomeGPR55agonistactivity.Rimonabantwasdevelopedasananti-obesitydrugbecauseofitsappetitesuppressantactivity,butwastakenoffthemarketbecauseofsideeffectsofdepressionandanxiety.UnderdevelopmentbySanofi-***entis,Acomplia(rimonabant)isaselectiveCB1endocannabinoidreceptorantagonistindicatedforthetreatmentofobesity.ItworksbyblockingendogenouscannabinoidbindingtoneuronalCB1receptors.Activationofthesereceptorsbyendoegenouscannabinoids,suchasanadamide,increasesappetite.Itisthemostadvancedendocannabinoidreceptorantagonistinclinicaldevelopmentandoffersanoveltherapeuticapproachtoappetitecontrolandweightreduction.3.Applicati***:Rimonabanthasaf***orablesafetyprofileandisgenerallywelltolerated.Rimonabantisprovingtobeaverypromisingapproachformanagingtwomajorandpreventableriskfactorsforcardiovasculardisease.Thisreviewsummarizesthe***ailableevidenceontheclinicalefficacyandsafetyofrimonabantasapotentialtherapyforobesityand***okingcessation.Rimonabanthydrochloridealsohaspotentialasatreatmentfor***okingcessationbecausetheendocannabinoidsystemisinvolvedinthebody'sresp***etotobaccodependence.)