DNP2/4-DinitrophenolPharmaceuticalRawMaterialsDNPSexPowderQuickDetail:DNPSynonyms:DNPDNPCASNo:51-28-5DNPMF:C6H4N2O5DNPMW:184.11DNPPurity:99%DNPPackage:1kg/foilbagDNPAppearance:Lightyellowtoyellowcrystals.Solubleinethanol,benzene,chloroformandether,dissolvedinlye,slightlysolubleincoldwater.DNPUsage:Weightlossdrug.Description:2,4-Dinitrophenolisusedinthemanufactureofdyes,woodpreservatives,andasapesticide.Theacute(short-term)effectsof2,4-dinitrophenolinhumansthroughoralexposurearenausea,vomiting,sweating,dizziness,headaches,andlossofweight.Chronic(long-term)oralexposureto2,4-dinitrophenolinhumanshasresultedintheformationofcataractsandskinlesi***,weightloss,andhascausedeffectsonthebonemarrow,centralnervoussystem(CNS),andcardiovascularsystem.Limitedornoinformationis***ailableonthedevelopmental,reproductive,orcarcinogeniceffectsof2,4-dinitrophenolinhumans.EPAhasnotclassified2,4-dinitrophenolforcarcinogenicity.Applicati***:2,4-Dinitrophenol(2,4-DNP,orsimplyDNP)isanorganiccompoundwiththeformulaHOC6H3(NO2)2.Itisayellow,crystallinesolidthathasasweet,mustyodor.Itsublimes,isvolatilewithsteam,andissolubleinmostorganicsolventsaswellasaqueousalkalinesoluti***.[1]Itisaprecursortootherchemicalsandisbiochemicallyactive,inhibitingenergy(ATP)productionincellswithmitochondriaandwasonceusedasadietaid.Itisproducedbyhydrolysisof2,4-dinitrochlorobenzene.DNPwasusedextensivelyindietpillsfrom1933to1938afterCuttingandTainteratStanfordUniversitymadetheirfirstreportonthedrug'sabilitytogreatlyincreasemetabolicrate.AfteronlyitsfirstyearonthemarketTainterestimatedthatprobablyatleast100,000pers***hadbeentreatedwithDNPintheUnitedStates,inadditiontomanyothersabroad.DNPactsasaprotonophore,allowingprot***toleakacrosstheinnermitochondrialmembraneandthusbypassATPsynthase.ThismakesATPenergyproductionlessefficient.Ineffect,partoftheenergythatisnormallyproducedfromcellularrespirationiswastedasheat.TheinefficiencyisproportionaltothedoseofDNPthatistaken.Asthedoseincreasesandenergyproductionismademoreinefficient,metabolicrateincreases(andmorefatisburned)inordertocompensatefortheinefficiencyandmeetenergydemands.DNPisprobablythebestknownagentforuncouplingoxidativephosphorylation.Theproductionor"phosphorylation"ofATPbyATPsynthasegetsdisconnectedor"uncoupled"fromoxidation.Specificati***:Productname2,4-DinitrophenolOthernameDNPCASregisternumber51-28-5MolecularformulaC6H4N2O5Assay99%AppearanceBuffmonocliniccrystalpowder.Package1kg/aluminiumfoilbagorasrequiredMinimumorderquantity10gShippingByexpresscourierShippingleadingtimeWithin24hoursafterreceivingthepaymentPaymentopti***WesternUnion,MoneyGram,T/TPriceNegotiated)