SorafenibtosylateChemicalName:4-{4[3-(4-chloro-3-trifluoromethyl-phenyl)ureide]phenoxy}pyridine-2-carboxamidep-toluenesulfonateProductAlias:toluenesulfonicsorafenibmesylateSorafenibSorafenibp-toluenesulfonicEnglishname:SorafenibtosylateEnglishSynonyms:Sorafenib(Nex***ar)CAS:475207-59-1Keywo***:Sorafenibtosylate,sorafenibtosylate,mesylateSorafenib,475207-59-1Molecularformula:C21H16ClF3N4O3.C7H8SO3MolecularWeight:637.03Appearance:yelloworwhitecrystallinepowderMeltingpoint:225-235℃Lossondrying:Lessthan0.5%He***ymetals:Lessthan10ppmTotalimpurities:lessthan1.0%Content:99%Packing:1kg/aluminumfoilbagUses:toluenesulfonicSorafenibisanovelmulti-targetanticancerdrugs,canactsimultaneouslyontumorcellsandtumorbloodvessels.Ithasadualanti-tumoreffects:eitherbyblockingtheRAF/MEK/ERK-mediatedcellsignalingPathwaydirectlyinhibittheproliferationoftumorcells,butalsobyinhibitingVEGFandplatelet-derivedHealthgrowthfactor(PDGF)receptorsandblocktheformationoftumorangiogenesis,indirectlyinhibitthegrowthoftumorcells.)