7-Keto-DHEAskype:tracy665emailtracyatycphardotcomProductName:7-Keto-DHEA(7-Keto-dehydroepiandrosterone)CAS:566-19-8Synonyms:DEHYDROEPIANDROSTERONE,7-KETO;5-androstene-3b-ol-7,17-dione;5-ANDROSTEN-3-BETA-OL-7,17-DIONEMF:C19H26O3MW:302.41Assay:99%Properties:WhitefinecrystallinepowderUsage:Pharmaceuticalrawmaterials,thehormoneDescription:7-keto-DHEAisaby-productofdehydroepiandrosterone(DHEA),achemicalthatisformedinthebody.DHEAisa"parenthormone"producedbyglandsnearthekidneys.ButunlikeDHEA,7-keto-DHEAisnotconvertedtosteroidhormonessuchasandrogenandestrogen.Taking7-keto-DHEAbymouthorapplyingittotheskindoesnotincreasethelevelofsteroidhormonesintheblood.Peopletake7-keto-DHEAtospeedupthemetaboli***andheatproductiontopromoteweightloss.7-keto-DHEAisalsousedtoimproveleanbodymassandbuildmuscle,increasetheactivityofthethyroidgland,boosttheimmunesystem,enhancememory,andslowaging.Applicati***:7-oxodehydroepiandrosterone(7-oxoDHEAandmorecommonlyknownasthebrandname7-keto)isoneofthreeoxygenatedmetabolitesofDehydroepiandrosterone,andthesethreeoxygenatedmetabolitesinterconvertwithoneanotherbutdonotconvertbackintoparentDHEA;7-ketosupplementationisawaytogetthesethreeoxygenatedmetaboliteswithoutusingDHEAsupplementation,andDHEAmayformandrogenicandestrogenichormonesviaanalternatemetabolicpathway(which7-ketodoesnotparticipatein).7-ketosupplementationismostlyknowntonotbehormonal;itcaninteractwithsteroidmetaboli***buttheexactmannerinwhichitdoesitnotfullyelucidated.Itdoesappeartoh***eanti-cortisolmechani***sastheenzymesthatactivatecortisol(fromtherelativelyinactiveprecursorsofcortisoneandcorticosterone)arethesamethatinterconverttheseoxygenatedmetabolites.Althoughitappearstobeanti-cortisolbyitsmechani***s,thereisinsufficientevidencetosupportthesemechani***sinthebodyfollowingoralsupplementation.Studiesusing7-ketosupplementationtendtonoteanincreasedmetabolicratelateronduringacaloricrestrictionperiod(whichissecondarytoreducingtherateofmetabolicratedeclineassociatedwithdieting,andbecomingarelativeincrease)althoughthequantityofdataonthisisprettyminimalifweexcludestudieswithpossibleconflictsofinterestorthosethatuse7-ketoalongsideamultitudeofsupplements.7-ketoappearstobeasomewhatpromisingnon-hormonalfatburningagentbutrequiresmoreevidenceonbothofthoseclaims.Howdoesitwork:7-keto-DHEAmightpromoteweightlossbyspeedingupthebody'smetaboli***.HowtoTake(recommendeddosage,activeamounts,otherdetails):Atypicalsupplementaldosageof7-ketois200-400mgdailyintwodivideddoses(100-200mg),somelimitedevidencesuggeststhatlowerdosesof50-100mgmaybeeffectiveforneuralpurposes.Theoptimaldosingscheduleandoveralldoseof7-ketoisnotyetknown,andtheabovedosagesarejustbasedonwhatisknowntoh***eefficacy.)