中文名称：血小板内皮细胞黏附分子-1***英文名称：Anti-CD31(PECAM-1)产品编号：PL030195R免疫原：KLHconjugatedsyntheticpeptidederivedfromhumanCD31C-terminus***类型：RabbitPolyclonalIgG产品规格：0.1mg/0.2mg包装情况：一支包装（原装进口、分装）其他名称：plateletendothelialcelladhesionmoleculeprecursor-1;PECAM-1;Adhesionmolecule;CD31antigen;CD31EndoCAM;Endocam;GPIIA;Pecam1;PECAM1CD31EndoCAM;Pecam1;Plateletendothelialcelladhesionmolecule;Platelet/endothelialcelladhesionmolecule.背景介绍：Thisproteinisacelladhesionmoleculeexpressedonplateletsandatendothelialcellintercellularjuncti***.TypeImembraneprotein.SIZE:738aminoacids;82536Da.SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.TISSUESPECIFICITY:Longisoformpredominatesalltissuesexamined,isoformDelta12wasdetectedonlyintracheaandisoformDelta14-15onlyinlung,isoformDelta14wasdetectedinalltissuesexaminedwiththestrongestexpressioninheart.PTM:PhosphorylatedonSerandTyrresiduesaftercellularactivation.SIMILARITY:Contains6Ig-likeC2-type(immunoglobulin-like)31,alsoknownasplateletendothelialcelladhesionmolecule1(PECAM1),isatypeIintegralmembraneglycoproteinandamemberoftheimmunoglobulinsuperfamilyofcellsurfacereceptors.Itisfoundonthesurfaceofplatelets,monocytes,neutrophils,andsometypesofT-cells,andmakesupalargeportionofendothelialcellintercellularjuncti***.CD31isimplicatedinseveralfuncti***,includingtransendothelialmigrationofleukocytes,angiogenesis,andintegrinactivation.Tyr-690playsacriticalroleinleukocytetransendothelialmigration(TEM)andisrequiredforefficienttraffickingofCD31toandfromthelateralborderrecyclingcompartment(LBRC)andisalsoessentialfortheLBRCmembranetobetargetedaroundmigratingleukocytes.CD31preventsphagocyteingestionofcloselyapposedviablecellsbytran***itting'detachment'signals,andchangesfunctiononapoptosis,promotingtetheringofdyingcellstophagocytes(theencounterofaviablecellwithaphagocyteviathehomophilicinteractionofCD31onbothcellsurfacesleadstotheviablecell'sactiverepulsionfromthephagocyte.Duringapoptosis,theinside-outsignalingofCD31issomehowdisabledsothattheapoptoticcelldoesnotactivelyrejectthephagocyteanymore.Thelackofthisrepulsionsignaltogetherwiththeinteractionoftheeat-mesignalsandtheirrespectivereceptorscausestheattachmentoftheapoptoticcelltothephagocyte,thustriggeringtheprocessofengulfment).CD31hasbeenusedtomeasureangiogenesisinassociationwithtumorrecurrence.Otherstudiesh***ealsoindicatedthatCD31andCD34canbeusedasmarkersformyeloidprogenitorcellsandrecognizedifferentsubsetsofmyeloidleukemiainfiltrates(granularsarcomas).交叉反应物种：Human,Mouse,Rat,Dog,Pig,Rabbit,Sheep,Bovine,（Pleasedecidethespecificitybyhomology）★☆★☆★深圳市豪地华拓生物科技有限公司★☆★☆★★☆★abbiotec***：美国Abbiotec公司网站★☆★★☆★pllabs***：加拿大PLlabs公司网站★☆★★☆★荧光金：美国Fluorochrome公司网站★☆★★☆★***盒：加拿大DBC公司www.dbc-★☆★★☆★美国GSI公司网站http://★☆★-------------------------------------------------------------------------------------------联系人：李先生手机：15217723134电话：0755-36953798传真：0755-86372180邮箱：lilyn@深圳市豪地华拓生物科技有限公司网址：http://地址：深圳市南山区创业路中兴工业城5栋518)