AZA1，azaspiracid-1，CRM-AZA1，原多甲藻酸贝类***，腹泻性贝毒，DSP贝类***的一种，属于原多甲藻酸（Azaspiracids）组。1996年2月被***分离出，生物起源尚无明确定论。为脂溶性聚醚化合物。毒性比较稳定，常规的烹饪和加工处理无法去除。检测方法为小鼠生物测定法和***液相色谱法。AZA1是***常见的类型，在贝体内***组成中所占比例***高。AZA2和AZA3分别是AZA1的8-甲基和22-脱甲基衍生物，在***贝类中也比较常见，同时也存在于浮游植物样品中。AZA4和AZA5是AZA3的3-羟基和23-羟基衍生物，在贝类体内含量很少。AZA6是AZA1的空间异构体，AZA7-10是AZA1的羟基化衍生物，AZA11是AZA2的羟基化衍生物，这几种衍生物在贝类体内也有发现，但含量非常少。推测AZA4、AZA5、AZA7、AZA8、AZA9和AZA10可能是贝类体内生物转化的产物AzaspiracidwasfirstdiscoveredinIrelandin1995afterahumanintoxicationeventlinkedtothec***umptionofshellfish[1]andhassincebeenobservedinwideareasofWestandNorthwestEurope[2,3].Azaspiracid-1AZA1)isamarinebiotoxinpossessinguniquespiroassemblieswithbothcarboxylandaminemoieties[4,5].ThemarinedinoflagellateProtoperidiniumcrassipeshasbeenimplicatedinproductionofazaspiracids[6].RecenttoxicologicalstudiesindicatethatAZA1posesasignificantthreattoc***umers.Intoxicationsymptomscanincludenausea,stomachcramps,headache,vomitinganddiarrhea.Long-termstudiesindicateapossiblecarcinogenicityandtumorpromotingabilities[7-8].ThemaximumpermissiblelevelofAZA1andsomeofanaloguesandmetabolitesinshellfishintheEUaccordingtothedirectiveEEC/225/2002implementingthelegislationEU/95/492iscurrently0.16mg/kginwholetissue.CRM-AZA1isdesignedforuseasaninstrumentcalibrationsolutiontoaidtheanalystinthedeterminationofAZA1inplanktonandshellfishsamples.Eachampoulecontainsapproximately0.5mLofsolutionwith1.47&plu***n;0.08μmol/LAZA1inmethanol.Azaspiracid(AZA1)MolecularFormula:***7H71***2FormularMolecularWeight:842.1MonoisotopicMass:841.4976CASRegistryNo.:214899-21-5)