SaxitoxinAcetate，STX，石房蛤***，***性贝毒，PSPSaxitoxin(SaxitoxinAcetate)蛤蚌***（石房蛤***）DescriptionSaxitoxin(STX)isaneurotoxinisolatedfrommarinedinoflagellatesAlexandriumtamarense.Itisaselectivesodiumchannelblocker.Themedicalimportanceofsaxitoxinisinrelationtoredtideinshellfishandcausestheparalyticshellfishpoisoning(PSP).Theblockingofthesodiumchannelproducesaflaccidparalysisthatle***esitsvictimcalmandc***ciousthroughtheprogressionofsymptoms.Deathisfromrespiratoryfailure.Saxitoxinhasbeenanimportanttoolincellularresearchindescribingthefunctionofthesodiumchannel.Molecularweigh419.39MolecularformulaC10H17O4•2C2H4O2CaseNumber220355-66-8SolubilityMeOH,EtOHorDMSOStorageStablein-25oCfor2yearFormLyophilizedsolidLyophilizedsolidAppearance(color)Whitetooff-WhiteWhitePurity≥95%byHPLC≥95%Method:Liquidchromatographywithpost-ColumnoxidationandfluorescencedetectionMaterial:Saxitoxin(STX)10μg/mlColumn:Co***osilC18-MS5μm,4.6x250mmMobilephase:2mMNaHSAin30mMNH4H2PO4(pH7.1):CH3CN=93:7Flowrate:0.8ml/minOxidation:7mMHIO4in50mMK2HPO4(pH9)Coilreaction:10mTeflontubing(0.3mmi.d.)at85℃Effluentacidified:0.5MCH3COOH0.25ml/minDetection:Fluorescence,Ex.330nm,Em.390nm)