BrevetoxinA，PbTx-1，裸藻***，短裸甲藻毒，双鞭甲藻***，***性贝毒，NSP裸藻***PbTX-1/BrevetoxinA，PbTX-1Source:EupenicilliumbrefeldianumSynonymsAscotoxin,Cyanein,DecumbinDescription:Amacrocycliclactonefromfungalsource,exhibitingawiderangeofantibioticactivity.CASnumber:20350-15-6Merckindex:11,1363Molecularweight:280.4MolecularFormula:C16H24O4Solubilityinformation:Methanol,Ethanol,***ane,DMSO,acetoneorethylacetateSpecificati***Appearance:Whitetooff-whitecrystallinesolid.Purity:Atleast98%byTLCλmax:Meltingpoint198°C-205°CSolubilityClearcolorlesssolutionat10mg/ml***ane.Clearcolorlesssolutionat10mg/mlMethanol.Storage-20°CApplicati***Inhibitorofproteintranslocationfromendopla***icreticulum(ER)totheGolgiapparatus.InhibitorofintracellularproteintransportandproteinsecretionWarningsTOXICClassificationmacrocycliclactoneantibiotic.AntifungalAntiviralProteinSynthesisInhibitorRelatedproductsForResearchuseonly.NotforHumanorDruguseGMP/APIgrade***ailableonrequestNogeneticallymodifiedorgani***sareused.Publicati***KhineAA,TamP,NutikkaA,LingwoodCA.BrefeldinAandfilipindistinguishtwoglobotriaosylceramide/verotoxin-1intracellulartraffickingpathwaysinvolvedinVerocellcytotoxicity.Glycobiology.2004Apr21SallesFT,HespanholAM,JaegerRG,MarquesMM.Brefeldin-Ainducesapoptosisinhumanadenoidcysticcarcinomaculturedcells.OralOncol.2004Jul;40(6):585-90.PadillaPI,Pacheco-RodriguezG,MossJ,VaughanM.NuclearlocalizationandmolecularpartnersofBIG1,abrefeldinA-inhibitedguaninenucleotide-exchangeproteinforADP-ribosylationfactors.ProcNatlAcadSciUSA.2004Mar2;101(9):2752-7.MossessovaE,CorpinaRA,GoldbergJ.CrystalstructureofARF1*Sec7complexedwithBrefeldinAanditsimplicati***fortheguaninenucleotideexchangemechani***.MolCell.2003Dec;12(6):1403-11.TogawaA,ItoH,KimuraF,ShimizuH,OhtsukaM,ShimamuraF,YoshidomeH,KatohA,MiyazakiM.Establishmentofgemcitabine-resistanthumanpancreaticcancercellsandeffectofBrefeldin-Aontheresistantcellline.Pancreas.2003Oct;27(3):220-4.VetterleinM,NiapirM,EllingerA,NeumullerJ,P***elkaM.BrefeldinAregulatedretrogradetransportintotheendopla***icreticulumofinternalisedwheatgermagglutinin.HistochemCellBiol.2003Aug;120(2):121-8.LeeMJ,ParkJY,LeeSY,LeeJS,JungDK,BaeYS,KwakJY.Modulationofc***titutiveanddelayedapoptosisbybrefeldinAinhumanneutrophils.IntImmunopharmacol.2003Jun;3(6):835-43.CampenotRB,SoinJ,BlackerM,LundK,EngH,MacInnisBL.BlockofslowaxonaltransportandaxonalgrowthbybrefeldinAincompartmentedculturesofratsympatheticneur***.Neuropharmacology.2003Jun;44(8):1107-17.PommepuyI,TerroF,PetitB,TrimoreauF,BelletV,RobertS,HugonJ,LabrousseF,YardinC.BrefeldinAinducesapoptosisandcellcycleblockadeinglioblastomacelllines.Oncology.2003;64(4):459-67.Edward_B_Neufeld,AdeleM.Cooney,JosefPitha,EliezarA.Dawidowicz,NancyK.Dwyer,PeterG.Pentchev,E.JoanBlanchette-MackieBrefeldinAapplicati***:IntracellularTraffickingofCholesterolMonitoredwithaCyclodextrinBJUInternational,Volume271,Number35,IssueofAugust30,1996pp.21604-21613)