CiclosporinAWakoGrade:forBiochemistryStoragecondition:Keepat2-10degreesC.Manufacturer:WakoSummary<PharmacologicandPhysiologicResearch><Autacoid>Likehormones,autacoidsexhibitstrongbioactivityin***allamounts,butunlikehormonestheyh***enoparticularproductionorgan,andtheyrefertobiologicallyactivesubstancesexpressingstrongphysiologicaleffectsimmediatelyatthesiteofproduction.Chemically,theyareclassifiedintoamines(suchashistamineandserotonin),peptides(suchasbradykininandangiotensin)andfattyacids(suchasprostaglandin).<Polypeptide>Theproductisatypicalimmunosuppressantusedforpreventionofgraftrejectionafterorgantransplantation.Itisacyclicpolypeptidec***istingof11aminoacidsandinhibitssecretionofinterleukin2fromhelperTcells,whichpromoteimmunereaction,andthusinhibitsimmunity.<Antibiotics/FolateMetaboli***relatedSubstances>Synonym***eACiclosporinA***A***e(USAN)27-400CiclosporinAntibioticS7481F1***NeoralOL27-400RamihyphinAS7481F1***eCASNO.59865-13-3MolecularFormulaC62H111N11O12MolecularWeight1,202.61Appearance:White,crystallinepowder-powderormassPurity:97.0+%(HPLC)Toxicity:LD50(rat,orl)1489mg/kg.MeltingPoint:148-151degreesCSpecificRotation:-244(D/20degreesC)(c=0.6,CHCl3)~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~CiclosporinAWakoGrade:forCellbiologyStoragecondition:Keepat2-10degreesC.Manufacturer:WakoSummaryItisarepresentativeimmunosuppressantusedforpreventionofrejectionreactionatthetimeoforgantransplantationanditbindstotheintracellularreceptorinTlymphocytesinhibitingIL-2andIFN-gammatranscription(calcineurininhibition).C***equently,itinhibitsactivationandproliferationofhelperTcellscontributingtoimmunereaction.Itisacyclicpolypeptidec***istingof11aminoacids.Synonym***eACiclosporinA***A***e(USAN)27-400CiclosporinAntibioticS7481F1***NeoralOL27-400RamihyphinAS7481F1***eCASNO.59865-13-3MolecularFormulaC62H111N11O12MolecularWeight1202.61Appearance:White,crystallinepowder-powderormassPurity:97.0+%(HPLC)Toxicity:LD50(rat,orl)1489mg/kg.MeltingPoint:148-151degreesCSpecificRotation:-244(D/20degreesC)(c=0.6,CHCl3)~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~如有更多其它***产品需求与查询,请及时接洽：info@express-cn.com或在我公司查询主页客户留言处（http://www.express-cn.com/expressgb/m）留下您的查询内容，我们即会在当天为您作出回复。伊普瑞斯科技有限公司info@express-cn.com总机：010-60206266传真：010-60206773www.express-cn.com)