ProteinCrosslinkers功能化蛋白交联剂蛋白质交联剂是一类小分子化合物，具有2个或者更多的针对特殊基团（-NH2、-COOH、-HS等）的反应性末端，可以和2个或者更多的分子分别偶联，从而使这些分子结合在一起，形成共轭蛋白。HomoCrosslinkers同端双功能交联剂HomobifunctionalCrosslinkersProteincrosslinkingagentspossessreactivemoietiesspecifictovariousfunctionalgroups(sulfhydryls,amines,carbohydrates,etc.)onproteins,peptides,orothermolecularcomplexes.BS3CrosslinkerBS3crosslinker(Bis[sulfosuccinimidyl]suberate;BS3)isawatersolublehomobifunctionalproteincrosslinker.DSSCrosslinkerDSScrosslinker(Disuccinimidylsuberate)isahomobifunctionalcrosslinkerthatiscellmembranepermeable.BS2GCrosslinkerBS2Gcrosslinker(Bis[Sulfosuccinimidyl]glutarate)isawatersolublehomobifunctionalproteincrosslinker.DSGCrosslinkerCAS#:79642-50-5DSGcrosslinker(Disuccinimidylglutarate)isahomobifunctionalcrosslinkingreagentthatismembranepermeable.DSPCrosslinkerDithiobis(succinimidylpropionate)(DSP)isahomobifunctionalcrosslinkerthatiscellmembranepermeable.DTSSPCrosslinkerDTSSPcrosslinker(3,3′-Dithiobis[sulfosuccinimidylpropionate])isahomobifunctionalproteincrosslinkerthatiscellmembraneimpermeable.Sulfo-EGSCrosslinkerSulfo-EGScrosslinker,Ethyleneglycolbis(sulfosuccinimidylsuccinate),isawatersolublehomobifunctionalcrosslinker.EGSCrosslinker,CAS#:70539-42-3EGScrosslinker,Ethyleneglycolbis(succinimidylsuccinate),isawaterinsolublehomobifunctionalcrosslinker.DSTCrosslinkerDSTcrosslinker(Disuccinimidyltartrate)isahomobifunctional,cleavablecrosslinkingreagentbyoxidizingreagents.DSSeb,CAS#23024-29-5DSSeb(Disuccinimidylsebacateismembranepermeable.DSSebcrosslinksviaamine-reactiveNHSestersatbothendsofa10-atom(14.1Å)spacerarmandmustdissolvedinanorganicsol-vent,suchasDMSOorDMF,thenaddedtoanaqueouscrosslinkingreactionHeteroCrosslinkers异端双功能交联剂HeterobifunctionalCrosslinkersProteincrosslinkingagentspossessreactivemoietiesspecifictovariousfunctionalgroups(sulfhydryls,amines,carbohydrates,etc.)onproteins,peptides,orothermolecularcomplexes.SMCCCrosslinkerSMCCcrosslinker(Succinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate)isaheterobifunctionalproteincrosslinkerwithamaleimidegroupthatissulfhydryl(thiol;-SH)reactiveandaNHSestergroupthatisaminereactive.Sulfo-SMCCCrosslinkerSulfo-SMCCcrosslinker(Sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate)isawatersoluble,heterobifunctionalcrosslinker.Sulfo-SANPAHCrosslinkerSulfo-SANPAHcrosslinker(N-Sulfosuccinimidyl-6-[4'-azido-2'-nitrophenylamino]hexanoate)isawatersoluble,heterobifunctionalproteincrosslinkerwithaspacerarmlengthof18.2Å.SMPHCrosslinkerSMPHcrosslinker(Succinimidyl-6-[ß-maleimidopropionamido]hexanoate)isawaterinsoluble,heterobifunctionalproteincrosslinkerwithanon-cleavablespacerarmlengthof14.3angstroms.PDPHCrosslinkerPDPHisacleavable,heterobifunctionalproteincrosslinkingreagent.MBSCrosslinkerCAS#:58626-38-3MBScrosslinkerisanon-cleavable,waterinsoluble,heterobifunctionalproteincrosslinkingreagentthatiscommonlyusedtocrosslinkhaptenstocarrierproteinsandenzymestoantibody.Sulfo-MBSCrosslinkerSulfo-MBScrosslinker(m-Maleimidobenzoyl-N-hydroxysulfosuccinimideester)isanon-cleavable,watersoluble,heterobifunctionalproteincrosslinkingreagentthatiscommonlyusedtocrosslinkhaptenstocarrierproteinsandenzymestoantibody.SPDPCrosslinkerSPDPcrosslinker(68181-17-9)isacleavable,waterinsoluble,aminoandthiol(sulfhydryl)reactiveheterobifunctionalproteincrosslinker.LC-SPDPCrosslinkerLC-SPDPcrosslinkerisacleavable,waterinsoluble,aminoandthiol(sulfhydryl)reactiveheterobifunctionalproteincrosslinker.Sulfo-LC-SPDPCrosslinkerSulfo-LC-SPDPcrosslinkingreagentisacleavable,watersoluble,aminoandthiol(sulfhydryl)reactiveheterobifunctionalproteincrosslinker.SIACrosslinkerN-Succinimidyliodoacetate(SIA)isanon-cleavable,heterobifunctionalproteincrosslinker.SBACrosslinkerSBAcrosslinker(N-Succinimidylbromoacetate)isasulfhydryl(thiol)andaminoreactiveheterobifunctionalproteincrosslinkingreagent.SMPBCrosslinkerSMPBcrosslinker(N-Succinimidyl4-[4-maleimidophenyl]butyrate)isaheterobifunctionalproteincrosslinkingreagentthatisreactivetowardsulfhydrylandaminogroups.BMPSCrosslinkerBMPSisanon-cleavable,waterinsoluble,heterobifunctionalproteincrosslinkerthatiscommonlyusedtocrosslinkhaptenstocarrierproteinsandenzymestoantibody.EMCSCrosslinker,CAS#:55750-63-5N-(e-Maleimidocaproyloxy)succinimideester(EMCS)isanon-cleavable,waterinsoluble,heterobifunctionalcrosslinkerthatiscommonlyusedtocrosslinkhaptenstocarrierproteinsandenzymetoantibody.GMBSCrosslinkerCAS#:80307-12-6GMBSisanon-cleavableheterobifunctionalproteincrosslinker.ANB-NOSCrosslinkerANB-NOScrosslinker(N-5-Azido-2-nitrobenzoyloxysuccinimide)isaheterobifunctionalproteincrosslinkerwithaspacerarmlengthof7.7angstroms.LC-SMCCCrosslinkerLCSMCCisanoncleavableandmembranepermeablecrosslinker.BMPH(N-β-maleimidopropionicacidhydrazide)CAS#:359436-61-6BMPHisashort,maleimide-and-hydrazidecrosslinkerforconjugatingsulfhydryls(cysteines)tocarbonyls(aldehydeorketones,suchasthoseformedbyoxidationofglycoproteincarbohydrates).BiotinCrosslinkers生物素交联试剂BiotinylationReagentsProteincrosslinkingagentspossessreactivemoietiesspecifictovariousfunctionalgroups(sulfhydryls,amines,carbohydrates,etc.)onproteins,peptides,orothermolecularcomplexes.Sulfo-NHS-BiotinSulfo-NHS-Biotin(Sulfosuccinimidylbiotin)isawatersolublebiotinylationreagent.NHS-BiotinNHS-Biotin(SuccinimidylBiotin;Succinimidobiotin)isaprimaryaminereactivebiotinylationreagent.Biotin-PFP五氟苯酚生物素酯CAS#120550-35-8Biotin-PFP五氟苯酚生物素酯CAS#120550-35-8Sulfo-NHS-LC-BiotinSulfo-NHS-LC-Biotin,Sulfosuccinimidyl6-(biotinamido)Hexanoate,isalongchainwatersolublebiotinylationreagentthatisreactivetowardprimaryaminegroups.NHS-LC-BiotinSuccinimidyl6-(biotinamido)hexanoate(NHS-LC-Biotin)isanamino-reactivebiotinylationreagentwithalongspacerarm.Sulfo-NHS-SS-BiotinSulfosuccinimidyl-2-(biotinamido)-ethyl-1,3'-dithiopropionate(Sulfo-NHS-SS-Biotin)isacleavable,water-soluble,amino-reactivebiotinylationreagent.N-琥珀酰亚氨基6-生物素氨己酸CAS#:72040-63-2N-琥珀酰亚氨基6-生物素氨己酸CAS#:72040-63-2BiotinamidohexanoicacidN-hydroxysuccinimideester6-生物素氨基己酸,CAS#:72040-64-36-生物素氨基己酸,CAS#:72040-64-3,N-(+)-Biotinyl-6-aminohexanoicacid6-[生物素酰氨基]己酸磺基琥珀酰亚胺酯CAS#:127062-22-06-[生物素酰氨基]己酸磺基琥珀酰亚胺酯CAS#:127062-22-0,Biotinamidohexanoicacid3-sulfo-N-hydroxysuccinimideestersodiumsaltNHS-SS-BiotinNHS-SS-Biotin,Succinimidyl-2-(biotinamido)-ethyl-1,3'-dithiopropionate,isanamine-reactivebiotinylationreagentthatcontainsareducibledisulfide.BiotinHydrazideBiotinHydrazide(Biotin-Hz)isacarbohydratereactivebiotinylationreagent.CAS#：66640-86-6Biotin-HPDPN-[6-(Biotinamido)hexyl]-3’-(2’-pyridyldithio)-propionamide(Biotin-HPDP)isasulfhydrylreactivebiotinylationreagentwithalongchain,cleavablespacerarm.Iodoacetyl-LC-BiotinIodoacetyl-LC-Biotin(N-Iodoacetyl-N'-BiotinylhexylenediamineorN-Biotinyl-N'-(iodoacetyl)-1,6-hexanediamine)reactswithsulfhydrylgroupstoformstablethioetherlinkages.D-BiotinD-Biotin,oftencalledVitaminH,D-(+)-Biotin,orsimplyBiotin,iswatersoluble.D-BiotinisoftenusedinconjunctionwithStreptavidinorImmobilizedStreptavidin.Biotin-ONP生物素-4-硝基苯酯CAS#33755-53-2Biotin-ONP(+)-生物素-4-硝基苯酯cas#33755-53-2Biotin-PEG3-CH2CH2NH23个重复单元的小分子PEG,一端连生物素，一段连氨基，分子量是418.55，CAS：359860-27-8Biotin-PEG3-CH2CH2COOH3个重复单元的小分子PEG,一端连生物素，一段连羧基，分子量是447.54，CAS：252881-76-8Biotin-PEG3-HydrazideBiotinylationreagentwithHydrazide,anda3PEGspacer.Biotin-PEG4-CH2CH2N3BiotinylationreagentwithAzide,anda3PEGspacerBiotin-NH-CH2CH2-S-S-pyrN/ABiotin-PEG3-NH-MalBiotinylationreagentwithNH-Mal,anda3PEGspacerBiotin-LCBiotinyl-6-aminohexanoicacid(Biotin-X)maybeusedinthebiosynthesisofbiotinylatedoligosaccharides.Biotinyl-6-aminohexanoicacidisfrequentlyuseasaderivativeN-hydroxysuccinimideester.Biotin-LC-LCAbiotinylatedcross-linkingreagentBiotin-SLC-NHSEsterN-Hydroxysulfosuccinimide(NHS)estersofbiotinarethemostpopulartypeofbiotinylationreagentsandNHS-activatedbiotinsreactefficientlywithprimaryaminogroups(-NH2)inalkalinebufferstoformstableamidebonds.Extendedchainincreasesavidinorstreptavidinbindingandreducespotentialsterichindranceofbiotinandconjugatedmolecule.Biotin-ONPAbiotinylatedcross-linkingreagentBiotin-LC-HydrazideBiotin-LC-LC-NHSEsterNHS-LC-LC-Biotinisadoublylong-chain,NHS-esteractivatedbiotinylationreagentforlabelingprimaryamines(e.g.,proteinlysines),whosemembranepermeabilityenablesittobeusedforintracellularlabeling.Sulfo-NHS-LC-LC-BiotinSulfo-NHS-LC-LC-Biotinisalong-chainbiotinylationreagentforlabelingantibodies,proteinsandothermoleculesthathaveprimaryamines.PFP-BiotinBiotinylationreagentwithapentafluorophenylestergroup.MorereactivethantheNHSestergroup,targetingbothprimaryandsecondaryamines.Suitableforbiotinlabelingofbothproteinsandaminoacids.Biotin–cadaverineBiotinandbiotinderivativesbindwithhighaffinitytobothavidinsandstreptavidins.Fmoc-D-Lys(Biotin)-OHAbiotinylatedcross-linkingreagentOtherCrosslinkers其他交联剂产品OtherModificationsProteincrosslinkingagentspossessreactivemoietiesspecifictovariousfunctionalgroups(sulfhydryls,amines,carbohydrates,etc.)onproteins,peptides,orothermolecularcomplexes.SATAProteinModifierN-Succinimidyl-S-Acetyl-Thioacetate(SATA)isusedtoconvertprimaryaminegroupsintoprotectedsulfhydryl(thiol;-SH)groups.(KMUS),CAS#:87981-04-211-马来酰亚胺十一烷酸N-琥珀酰亚胺酯(KMUS),CAS#:87981-04-2Sulfo-NHS-AcetateSulfo-NHS-Acetateacylatingagent(SulfosuccinimidylAcetate)isawatersoluble.Traut'sReagentTraut'sReagent(2-IminothiolaneHCl)iscommonlyusedtoconvertprimaryaminesintosulfhydrylgroupsinaone-stepprocessiscalledthiolation.3-马来酰亚胺基丙酸(MPA),CAS#:7423-55-43-马来酰亚胺基丙酸(MPA),CAS#:7423-55-44-马来酰亚胺丁酸(MBA)CAS#:57078-98-54-马来酰亚胺丁酸(MBA)CAS#:57078-98-511-马来酰亚胺十一烷酸(KMUA),CAS#57079-01-311-马来酰亚胺十一烷酸(KMUA),CAS#57079-01-3HPGHPGproteinmodificationreagent(p-Hydroxyphenylglyoxal)reactswitharginineresiduestogivealargeincreaseinabsorbanceatapproximately340nm.IodoaceticAcidIodoaceticAcidis≥99.0%pure.Iodoaceticacidisusedforthemodificationandalkylationofsulfhydryls(-SH)incysteineresiduesfoundinproteinsandpeptides.2-马来酰亚胺基乙酸(MAA),CAS#25021-08-32-马来酰亚胺基乙酸(MAA),CAS#25021-08-3Sulfo-EMCS,CAS#:215312-86-0Sulfo-EMCS,CAS#:215312-86-0CAS55750-61-3,马来酰亚胺基乙酸琥珀酰亚胺酯(AMAS)CAS55750-61-3,马来酰亚胺基乙酸琥珀酰亚胺酯(AMAS)双马来酰亚胺基乙烷,CAS#:5132-30-9双马来酰亚胺基乙烷,CAS#:5132-30-92-(2-(2-氨基乙氧基)乙氧基)乙基氨基甲酸叔丁酯,CAS#:153086-78-32-(2-(2-氨基乙氧基)乙氧基)乙基氨基甲酸叔丁酯,CAS#:153086-78-3N,N,N',N'-四甲基对苯二胺,CAS#:100-22-1N,N,N',N'-四甲基对苯二胺,CAS#:100-22-13,3'-二硫代双(磺酸琥珀酰亚氨基丙酸酯)CAS#:81069-02-53,3'-二硫代双(磺酸琥珀酰亚氨基丙酸酯)CAS#:81069-02-5BMPAModifierBMPAModifier(N-ß-Maleimidopropionicacid)canbeusedasaproteincrosslinkerorsulfhydryl(-SH)tocarboxylicacid(-COOH)modificationreagent.EDC-HCl(EDAC-HCl)EDC-HCl(EDAC-HCl)zero-lengthcrosslinkerfromProteoChemisUltraPure,andisusedtoconjugatecarboxylfunctionalgroupstoprimaryaminesasfoundinpeptidesandproteins.NHSN-hydroxysuccinimide(NHS)prolongsthelifetimeofamino-reactivemoietiesformedatcarboxylicacidsandincreasestheefficiency.Sulfo-NHSN-hydroxysulfosuccinimide(Sulfo-NHS)isusedinconjunctionwithEDC-HCl(EDAC-HCl)toconvertcarboxylgroupstoSulfo-NHSesterswhichreactamines.DCCN,N'-Dicyclohexylcarbodiimide(DCC)isazerolengthcouplingreagent.CDIN,N'-Carbodiimide(CDI)isazerolengthcrosslinkingreagentusedtocoupleprimaryaminestocarboxyllicacidfunctionalgroups.IPTG,CAS#:367-93-1异丙基1-硫代-β-D-半乳糖吡喃糖苷（IPTG）是β–半乳糖苷酶的活性诱导物质，常用于蓝白斑筛选及IPTG诱导的细菌内的蛋白表达等。当pUC系列的载体DNA（或其他带有lacZ基因载体DNA）以lacZ缺失细胞为宿主进行转化时、或用M13噬菌体的载体DNA进行转染时，如果在平板培养基中加入X–Gal和IPTG，由于β–半乳糖苷酶的α–互补性，可以根据是否呈现白色菌落（或噬菌斑）而方便地挑选出基因重组体。此外，它还可以作为具有lac或tac等启动子的表达载体的表达诱导物使用。PNPP,CAS#:4264-83-94-硝基苯基磷酸二钠盐CAS#:4264-83-96-马来酰亚胺基己酸CAS#:55750-53-36-Maleimidohexanoicacidmaybeusedasaspacerintheconstructionofdrugandothertypesofbioconjugates.6-MaleimidohexanoicacidisusedwithN-hydroxysuccinimideesterasabifunctionalcross-linkingbeforthiolgroups(SH-groups)inmembraneproteins.6-(叔丁氧羰基-氨基)己酸CAS,#51513-80-56-(叔丁氧羰基-氨基)己酸CAS,#51513-80-5TMPD,CAS#:637-01-4N,N,N',N'-四甲基对苯二胺碘乙酸,CAS#:39028-27-8碘乙酸N-羟基琥珀酰亚胺酯TSAT(tris-(succinimidyl)aminotriacetate)TSATistris-(succinimidyl)aminotriacetate,anoveltrifunctionalcrosslinkerthatcontainsthreeshortspacersarmslinkedtoacentralnitrogenatom,eachendinginanamine-reactiveNHS-estergroup.DST(disuccinimidyltartrate)Thisproductissensitivetomoisture.Thevialispackagedinaresealablebagwithadesiccanttoreduceexposuretomoisture.Aftercoldstorage,equilibratethevialtoroomtemperaturebeforeopeningtoreducecondensationinsidethevial.Makefreshsolutions.Storageofstocksolutionsisnotrecommended.Afteruse,returnthevialtotheresealablebag.Closethebagandstoretheproductattherecommendedtemperature.EMCH(N-ε-maleimidocaproicacidhydrazide)CAS#:151038-94-7EMCHisamid-length,maleimide-and-hydrazidecrosslinkerforconjugatingsulfhydryls(cysteines)tocarbonyls(aldehydeorketones,suchasthoseformedbyoxidationofglycoproteincarbohydrates).KMUH(N-κ-maleimidoundecanoicacidhydrazide)CAS#:1593661-78-9马来酰亚胺基十一烷酰肼三氟乙酸盐BMB(1,4-bismaleimidobutane)CAS#:28537-70-4BMBisamid-length,maleimidecrosslinkerforcovalent,irreversibleconjugationbetweensulfhydrylgroups(e.g.,proteinorpeptidecysteines).BMH(bismaleimidohexane)CAS#:4856-87-5BMHisalong-arm,maleimidecrosslinkerforcovalent,irreversibleconjugationbetweensulfhydrylgroups(e.g.,proteinorpeptidecysteines).TMEA,CAS#:139112-38-2TMEAisatrifunctionalcrosslinkercontainingthreereactivemaleimidegroupstoenablethree-wayconjugationandpolymerizationofsulfhydryl-containingmolecules.DTMECAS#:71865-37-7Thisproductissensitivetomoisture.Thevialispackagedinaresealablebagwithadesiccanttoreduceexposuretomoisture.Aftercoldstorage,equilibratethevialtoroomtemperaturebeforeopeningtoreducecondensationinsidethevial.Makefreshsolutions.Storageofstocksolutionsisnotrecommended.Afteruse,returnthevialtotheresealablebag.Closethebagandstoretheproductattherecommendedtemperature.GeneraldescriptionDTMEisahomobifunctional,maleimidecrosslinSATP,CAS#:84271-78-3ThermoScientificPierceSATPisalong-chain(4.1angstromspacerarm)reagentforcovalentmodificationofprimaryaminesandadditionofaprotectedyetexposablesulfhydrylgroup,enablingheterobifunctionalcrosslinkingstrategies.AEDPAEDPisanamine-and-carboxylcompoundwithaninternaldisulfidebond.AEDPenablesconstruction,extensionandmodificationofseveralfunctionalgroupsonproteinsandsurfaces.N-丙烯酰氧琥珀酰亚胺,CAS#:38862-24-7N-丙烯酰氧琥珀酰亚胺,CAS#:38862-24-7Zero-LengthCrosslinkers零长度交联剂Sulfo-NHSProteinCrosslinkers功能化蛋白交联剂关于YARE：YARE-PEG修饰性PEG产品特点及技术优势：我们已经为我们的客户提供了十年的PEG修饰剂服务，我们一直致力于降低价格，提高品质！1、提供多种官能团修饰，性能好，纯度高，产品分子量可定制，产品聚合分散度（PDI）小于1.05；2、生产工艺简化，杂质低，品质稳定；3、批量生产，成本可控；4、可提供2000多种产品规格；5、其他特殊规格可提供定制。ProteinCrosslinkers功能化蛋白交联剂PEG修饰剂,聚乙二醇修饰剂,PEG衍生物,聚乙二醇衍生物,单官能团PEG,PEG-NH2,PEG-COOH,PEG-SH,PEG-NHS,PEG-SC,PEG-MAL,PEG-N3,PEG-SPA,PEG-ALD,PEG-Silane,PEG-Hydrazide,PEG-Alkyne,双官能团PEG,NH2-PEG-NH2,COOH-PEG-COOH,Mal-PEG-Mal,NHS-PEG-NHS,NH2-PEG-COOH,Boc-NH-PEG-OH,FMOC-NH-PEG-COOH,NH2-PEG-OH,SH-PEG-COOH,SH-PEG-NH2,MAL-PEG-NHS,Biotin-PEG-NH2,多臂PEG,4臂PEG,6臂PEG,8臂PEG,4arm,6arm,8arm,4arm-PEG-NH2,4arm-PEG-COOH,4arm-PEG-SH,8Arm-PEG-SG,短链PEG,单分散PEG,Boc-NH-PEG2-NH2,Boc-NH-PEG2-COOH,SH-PEG3-NH2,磷脂PEG,PEG-PE,mPEG-DSPE,DSPE-PEG-NH2,DSPE-PEG-COOH,DSPE-PEG-Biotin,DSPE-PEG-Mal,聚乳酸PEG,PEG-PLA,PEG-PLGA,PLGA-PEG-PLGA,PLA-PEG-PLA,PLGA-PEG-COOH,PLGA-PEG-NH2,PLGA-PEG-FA,CY7-PEG-NH2,FITC-PEG-NH2,cy5-PEG-DSPE,cy3-PEG-DSPE,温敏水凝胶,NANOCS,ProChimia,Surfaces,Rapp-polymere,Laysan,LaysanBio,Creative,PEGWorks,SunBio,BroadPharm,POLYPURE,NOF,QUANTA,Chemicell,Celares,BioVectra-----------------------------------------------------------标准品,对照品,NIBSC标准品,抗原,抗体,标品,英国国家生物标准与检定所标品,美国药典,USP,欧洲药典,EP,加拿大TRC,中检所-----------------------------------------------------------聚乙二醇修饰化学和PEG修饰剂选择指南移液器的日常清洗和维护保养样品瓶和隔垫的选择指南)